Name:
Atracurium besylate.Formerly known as: tracrium needle
Characters: injections.
Indications: Suitable for endotracheal intubation and muscle relaxation required surgery thoracic and abdominal muscle relaxation.
Usage: intravenous: Average dose for adults is 0.3-0.6mg/kg, 15-35 minutes to maintain muscle relaxation. To extend the full blocking time, supplement doses used 0.1-0.2mg/kg. Intravenous infusion: In the long surgery to 0.3-0.6mg/kg start dose, you can continue to stop every minute 0.005-0.01mg/kg dose infusion for maintaining neuromuscular blocking effects.
Adverse reactions and attention: with the same majority of neuromuscular blocking agents, can cause the release of histamine, the occurrence of skin flushing, transient hypotension, and occasionally can cause bronchospasm. Therefore, those who are allergic to the chemicals banned. In myasthenia gravis, neuromuscular disease, severe electrolyte imbalance in patients using this manipulation to be careful because it can strengthen other non-depolarizing agent. With severe cardiovascular disease, to the chemicals produced transient hypotension is more sensitive, it is suggested that for fractionated slow intravenous injection.
Other: The goods and inhaled anesthetic gases such as Halon, isoflurane and halothane thinking may be used simultaneously enhancing its neuromuscular blocking effect. And aminoglycosides, antibiotics is too many, a lithium salt, procainamide quinidine or mountains amine used simultaneously possible to enhance the role of nerve block. This product is not with the depolarizing muscle relaxants such as succinylcholine chloride combination, may occur due to blocking effects of prolonged and difficult composite anticholinergic drugs enzyme reverse.
Anesthesia with muscle relaxant: Atracurium acid is a kind of anesthesia with muscle relaxants, for the treatment of endotracheal intubation and muscle relaxation required surgery thoracic and abdominal muscle relaxation, with the majority same neuromuscular blocking agents, can cause the release of histamine, the occurrence of skin flushing, transient hypotension, and occasionally can cause bronchospasm.
Acid atracurium and inhaled anesthetic gases such as Halon, isoflurane and halothane thinking may be used simultaneously enhancing its neuromuscular blocking effect. And the aminoglycosides, antibiotics is too many, a lithium salt, quinidine or mountains procaine amine used simultaneously possible to enhance the role of nerve block. This product is not with the depolarizing muscle relaxants such as succinylcholine chloride combination, may occur due to blocking effects of prolonged and difficult composite anticholinergic drugs enzyme reverse. Allergic to the chemicals were banned. In myasthenia gravis, neuromuscular disease, severe electrolyte imbalance in patients using this manipulation to be careful because it can strengthen other non-depolarizing agent. With severe cardiovascular disease, to the chemicals produced transient hypotension is more sensitive, it is suggested that for fractionated slow intravenous injection.
Identification: room temperature acid Atracurium is white to light yellow crystalline powder, hygroscopic, odorless, soluble in chloroform or ethanol, dissolved in water, almost insoluble in ether.
(A) the product of about 10mg, dissolved in dilute hydrochloric acid 1ml, dropping dilute bismuth potassium iodide solution, namely a yellow precipitate.
(2) to take this product, add 0.1mol / L hydrochloric acid solution containing 50μg per 1ml of the solution, according to spectrophotometry (Chinese Pharmacopoeia 2000 edition two Appendix Ⅵ A) measured at 280nm wavelength of maximum absorption.
(3) The infrared absorption spectrum should be consistent with the reference of the map.
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