Carbidopa Description

Synonyms: (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate

CAS No: 28860-95-9

Molecular formula: C10H14N2O4

Molecular weight: 226.229

Purity: >98%

Melting point: 203 to 205 °C (397 to 401 °F)

Carbidopa is a borderline dopa-decarboxylase inhibitor which exhibits a audible pharmacological action alone if accustomed in aggregate with levodopa. Carbidopa inhibits the borderline decarboxylation of levodopa to dopamine. As, clashing levodopa, carbidopa does not cantankerous the blood-brain barrier, able academician concentrations of dopamine are produced with lower doses of levodopa.

In the analysis of parkinsonism carbidopa is administered in aggregate with levodopa to acquiesce a lower dosage of the latter, a added accelerated access of a response, and a acknowledgment of adverse effects.

Carbidopa is used with l-DOPA (l-3,4-dihydroxyphenylalanine) to amusement Parkinson's ache (PD). PD patients display lower accident of a lot of cancers including pancreatic cancer, but with the notable barring of melanoma. The decreased blight accident is not due to l-DOPA; however, the appliance of Carbidopa to this abnormality has not been investigated. Here, we activated the antecedent that Carbidopa, absolute of l-DOPA, ability arm-twist an anticancer effect.