Unlike abounding laxative products, lubiprostone does
not appearance signs of tolerance, dependency, or adapted serum electrolyte
concentration. There was no backlash aftereffect afterward abandonment of
treatment, but a bit-by-bit acknowledgment to pre-treatment bowel movement
abundance should be expected.
Minimal administration of the biologic occurs above the
actual gastrointestinal tissues. Lubiprostone is rapidly metabolized by
reduction/oxidation, advised by carbonyl reductase. There is no metabolic
captivation of the hepatic cytochrome P450 system. The assessable metabolite,
M3, exists in actual low levels in claret and makes up beneath than 10% of the
absolute administered dose.
Data announce that metabolism occurs locally in the
abdomen and jejunum.
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