Kacip Fatimah Safety of the herb, not genotoxic

Kacip Fatimah aswell accepted as Labisia pumila, is a acceptable herbal anesthetic with a continued history in the Malay community. It has been acclimated by abounding ancestors of Malay women to abet and facilitate accouchement as able-bodied as a post-partum medicine. We activated the genotoxic abeyant of Kacip Fatimah in cartilage bottom beef acquired from Sprague-Dawley rats application micronuclei accumulation as the toxicological endpoints. 5 groups of 5 macho rats anniversary were administered orally for two after canicule with doses of 100, 700 and 2000 mg/kg physique weight of Kacip Fatimah extract attenuated in distilled water.

Micronucleus alertness was acquired from cartilage bottom beef of the animals afterward accepted protocols. No statistically cogent access in micronucleated irised erythrocytes was empiric at any dosage akin and sacrifice/harvest time point. However, a cogent abatement in irised erythrocytes / normochromatic erythrocytes arrangement was empiric from the accomplished dosage akin (2000 mg/kg of physique weight) at 48h autumn time point. In this study, we advised the aftereffect of Kacip Fatimah on beastly cartilage bottom beef application micronuclei accumulation to appraise the genotoxicity of the herb. The in vivo rodent micronucleus appraisal of Kacip Fatimah (Labisia pumila) extract. Trop Biomed. 2006 Dec; Zaizuhana S, Puteri J Noor MB, Noral'ashikin Y, Muhammad H, Rohana AB, Zakiah I. Herbal Anesthetic Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.