Halofuginone
is a low atomic weight quinazolinone alkaloid, and a almighty inhibitor of
collagen alpha1(I) and cast metalloproteinase 2 (MMP-2) gene expression.
Halofuginone aswell finer suppresses bump progression and alteration in mice.
Collgard Biopharmaceuticals is developing halofuginone for the analysis of
scleroderma and accustomed drop biologic appellation from the U.S.
Halofuginone,
a absolutely constructed baby molecule, is a almighty and careful regulator of
stromal corpuscle activation, corpuscle clearing and Collagen type I synthesis,
a action that has been articular as a 'master switch' in the body's tissue
adjustment process.
Halofuginone
is a almighty inhibitor of collagen a1(I) and cast metalloproteinase 2 (MMP-2)
gene expression. Halofuginone aswell suppresses extracellular cast degradation
and corpuscle proliferation. The abstruse antitumoral aftereffect of
halofuginone is attributed to its accumulated inhibition of the bump stromal
support, vascularization, invasiveness, and corpuscle proliferation.
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