Venlafaxine
is a phenethylamine bicyclic derivative. It blocks the reuptake of serotonin,
noradrenaline and, to a bottom extent, dopamine. The reuptake furnishings of
venlafaxine are dosage dependent. At low doses (< 150 mg/day) it acts alone
on serotonergic transmission, like the SSRIs. At abstinent doses (>150
mg/day) venlafaxine acts on serotonergic and noradrenergic systems, admitting
at top doses (>300 mg/day) it affects serotonergic, noradrenergic and dopaminergic
neurotransmission 14.
The
aggregate of the furnishings on the reuptake mechanisms appears to be amenable
for the antidepressant activity of the drug.
Venlafaxine
has negligible affection for muscarinic, adrenergic, or histamine receptors.
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