What is Atorvastatin?

Atorvastatin is rapidly captivated afterwards articulate administering with best claret concentrations accomplished in 1 to 2 hours. The complete bioavailability of atorvastatin (parent drug) is about 14% and the systemic availability of HMG-CoA reductase inhibitory action is about 30%. The low systemic bioavailability is due to presystemic approval by gastrointestinal film and first-pass metabolism in the liver.

Atorvastatin is abundantly metabolized to ortho- and parahydroxylated derivatives and assorted beta-oxidation products. In vitro inhibition of HMG-CoA reductase by ortho- and parahydroxylated metabolites is agnate to that of atorvastatin. About 70% of circulating inhibitory action for HMG-CoA reductase is attributed to alive metabolites. CYP3A4 is aswell complex in the metabolism of atorvastatin.