Product name: Anti-Fe65 protein
Description: FE65, FE65L1 and FE65L2 are associates of the FE65 protein family. FE65 is an adaptor protein with protein-protein alternation domains including a WW area followed by two phosphotyrosine alternation domains (PID1 and PID2). Amyloid beta forerunner protein (APP) binds to PID2 and undergoes consecutive cleavage. First alpha-/beta secretases carve and absolution the ectodomain into the extracellular environment. Subsequent processing by the gamma-secretase circuitous after-effects in the APP intracellular area (AICD) and the beta-amyloid peptides. The closing A-beta bits anatomy the capital apparatus of amyloid plaques in patients with Alzheimer's disease. FE65 ancestors associates can adapt APP processing, consistent in animated levels of A-beta. Double knock-out mice of FE65 and FE65L1 affectation a phenotype that occurs in animals defective APP ancestors members, acknowledging a anatomic alternation amid FE65 and APP.
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From:Elisa test kits
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