Anti-GR (Glucocorticoid receptor) Classification

GR (Anti-GR (Glucocorticoid receptor)) currently found in the

glucocorticoid receptor GRα including normal and variant fragments

GRβ two subtypes, both of which are the same glucocorticoid receptor

gene transcript splicing through different cut results. The latter

can bind to DNA, but not with steroid binding, and therefore may bind

to DNA by interfering GRα and become steroid inhibitor. GRα and GR

β identical to the first 727 amino acids, starting from amino acid

728 GRα has 50 amino acid sequence, while only 15 amino acids of GR

β. At the mRNA level, both of which contain 1 to exon 8, except for

the GRα containing exon 9α, while GRβ contains 9β exons. GRα in

almost all tissues and cells were expressed in most cells, its

content is far more than GRβ, and glucocorticoids primarily through

a combination of GRα exerts its biological effects. Therefore GRα

expression, biochemical characteristics and physiological functions

such detailed studies have already been made, but the GRβ studies

concern only in recent years, the study found GRβ on GRα functional

antagonism may be physiological glucocorticoid and pharmacological

function plays an important negative regulatory role.


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From:Elisa test kits