Paricalcitol Description

Paricalcitol is a constructed noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been apparent to abate parathyroid hormone (PTH) levels. This abettor aswell increases the announcement of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic beef and cyclin-dependent kinase inhibitors, consistent in bump corpuscle apoptosis and bump corpuscle adverse into accustomed phenotypes.

Paricalcitol is alone begin in individuals that accept used or taken this drug. It is a constructed vitamin D analog. Paricalcitol has been used to abate parathyroid hormone levels. Paricalcitol is adumbrated for the blockage and analysis of accessory hyperparathyroidism associated with abiding renal failure. Paricalcitol is drugally alive vitamin D analog of calcitriol with modifications to the ancillary alternation (D2) and the A (19-nor) ring. Preclinical andin vitro studies accept approved that paricalcitol's drugal accomplishments are advised through bounden of the VDR, which after-effects in the careful activation of vitamin D acknowledging pathways. Vitamin D and paricalcitol accept been apparent to abate parathyroid hormone levels by inhibiting PTH amalgam and secretion.